Case Files Pharmacology by Eugene Toy

Author:Eugene Toy
Language: eng
Format: epub
Publisher: McGraw-Hill Education
Published: 2014-04-14T16:00:00+00:00

Structure

Ursodiol is derived from 7-hydroxycholesterol and is a naturally occurring component in bile.

Administration

Ursodiol is administered orally, two to three times a day, and complete dissolution of stones may require a year. Treatment effectiveness should be monitored by diagnostic ultrasound.

COMPREHENSION QUESTIONS

33.1 Ursodiol reduces the size of common bile duct gallstones by which of the following mechanisms?

A. Chelating Ca2+ out of the stone

B. Decreasing the synthesis of bile

C. Increasing the cholesterol content in bile

D. Slowly dissolving cholesterol from the stone

33.2 A 35-year-old woman is noted to have cholelithiasis. She opts for medical therapy with ursodiol. Complete dissolution of a gallstone by ursodiol typically requires how long?

A. Several hours

B. Weeks

C. Months to years

D. Several years

33.3 Ursodiol has been useful to treat which of the following conditions?

A. Cholestasis of pregnancy

B. Cirrhosis

C. Diabetes mellitus

D. Pancreatitis resulting from trauma

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